Fat Loss · Evidence Preliminary
Yohimbine HCl
A stimulant compound studied for stubborn fat — carries significant cardiovascular and psychiatric risks.
Dosage
0.2 mg/kg bodyweight in research; many people do not tolerate this dose
Timing
Fasted, before low-intensity cardio
Evidence
Preliminary
Overview
Yohimbine has a legitimate research signal for stubborn fat loss in already-lean athletes doing fasted cardio, but the risk profile is serious. It is not a general fat-loss supplement and is not appropriate for most people.
Benefits
- →May increase fat oxidation from stubborn regions in lean athletes during fasted cardio
Best for
Stacks with
Side effects
- • Anxiety and panic attacks
- • Elevated blood pressure and heart rate
- • Nausea, sweating, tremor
- • Insomnia
Warnings & cautions
- ⚠Do not use if you have hypertension, cardiovascular disease, arrhythmia, or a history of anxiety or panic disorders.
- ⚠Do not combine with caffeine, other stimulants, MAOIs, or antidepressants.
- ⚠Avoid during pregnancy or breastfeeding, and in children or adolescents.
- ⚠Stop use immediately if you experience chest pain, palpitations, severe anxiety, or a hypertensive crisis and seek emergency care.
Drug & condition interactions
- • MAOIs, antidepressants, blood-pressure medications, stimulants.
Evidence notes
Limited human evidence for lean-athlete fat-loss applications. Side-effect profile is significant.
Research references
- [1] Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. — Res Sports Med, 2006; 14:289–299
Medical disclaimer
This page is for general educational purposes only and is not medical advice. Individual response to supplements varies. Consult a licensed healthcare provider before starting any supplement — especially if you are pregnant, breastfeeding, under 18, taking prescription medication, or managing a medical condition.